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Home - Products - Proteasome/Ubiquitin - Cysteine Protease - JTE-607 HCl

JTE-607 HCl

CAS No. 188791-09-5

JTE-607 HCl( JTE-607 | JTE 607 | JTE-607 HCl )

Catalog No. M23861 CAS No. 188791-09-5

JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JTE-607 HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
  • Description
    JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
  • In Vitro
    RT-PCR Cell Line:human peripheral blood mononuclear cells (PBMCs)Concentration:100 nM Incubation Time:20 hours Result:Reduced the increase in the level of mRNAs of TNF-α, IL-1b, IL-6 and IL-8.
  • In Vivo
    Animal Model:Male C57BL/6 mice (5 to 6 weeks old) are sensitized by injecting Corynebacterium parvumDosage:0.3, 1, 3, 10 mg/kg Administration:Administered intravenously 10 min before the LPS challenge. Result:Showed dose dependent inhibition of the mortality at 0.3 to 10 mg/kg and significant effect at 3 and 10 mg/kg.
  • Synonyms
    JTE-607 | JTE 607 | JTE-607 HCl
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Cysteine Protease
  • Recptor
    Cystine
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    188791-09-5
  • Formula Weight
    525.3
  • Molecular Formula
    C22H29Cl4N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (418.51 mM)
  • SMILES
    O=C(N(CC)C1=CC=CC=C1)C2=CC(Cl)=C(OCCN3CCN(C)CC3)C(Cl)=C2O.[H]Cl.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Borozdenkova S, Mant TG, Allen E, Pu K, Hoshino S, Jurcevic S. Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers. Int Immunopharmacol. 2011 Nov;11(11):1837-43. doi: 10.1016/j.intimp.2011.07.013.
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